Oxidative Stress in Seminal Plasma Negatively Influences Sperm Quality in Infertile Males

Authors

  • Roshan Kumar Mahat Department of Biochemistry, American International Institute of Medical Sciences (AIIMS) and GBH General Hospital, Udaipur (RJ)
  • Dhananjay Vasantrao Bhale Department of Biochemistry, MGM Medical College and Hospital, Aurangabad (MH)
  • Vedika Rathore Department of Biochemistry, Shyam Shah Medical College, Rewa (MP)

DOI:

https://doi.org/10.15850/ijihs.v11n1.3079

Keywords:

Male infertility, Malondialdehyde, Sperm quality.

Abstract

Objective: To investigate the association between malondialdehyde concentration in the seminal plasma of infertile men and sperm quality.

Methods: This case-control study included 60 male participants ranging from 25-40 years old with half of them were fertile and the other half were infertile. Semen analysis was performed as per the WHO standards, and spectrophotometric measurement of seminal plasma malondialdehyde level was done.

Results: Results showed that infertile men had significantly a higher mean level of malondialdehyde in their seminal plasma than fertile men (p<0.001), which was inversely associated with sperm count and motility. Also, malondialdehyde was positively associated with abnormal sperm morphology.

Conclusions: Elevated malondialdehyde levels in seminal plasma are associated with poor sperm quality. Malondialdehyde testing can, therefore, be used to diagnose and predict the outcome of male infertility. Antioxidants should also be administered to men with infertility to help counteract the effects of oxidative stress.

Author Biographies

  • Roshan Kumar Mahat, Department of Biochemistry, American International Institute of Medical Sciences (AIIMS) and GBH General Hospital, Udaipur (RJ)
    Assistant Professor, Department of Biochemistry
  • Dhananjay Vasantrao Bhale, Department of Biochemistry, MGM Medical College and Hospital, Aurangabad (MH)
    Professor and Head, Department of Biochemistry
  • Vedika Rathore, Department of Biochemistry, Shyam Shah Medical College, Rewa (MP)
    Associate Professor (D), Department of Biochemistry

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Published

2023-03-31

Issue

Vol. 11 No. 1 (2023)

Section

Articles

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Authors retain copyright and grant International Journal of Integrated Health Sciences right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to freely share and remix the work with an acknowledgement of the work's authorship and initial publication in International Journal of Integrated Health Sciences.